In a nutshell, we want to stop trying to do the ‘wrong things righter’ (an over-emphasis on efficiency and/or cost-management), and instead do the right things (an emphasis on effectiveness and flow-management).
If you think of a process as a chain, you want to find and strengthen the weakest link in that chain. Any effort to strengthen other links doesn’t strengthen the chain (system).
To extend that analogy, sometimes, over-strengthening the non-weakest link can make the weakest link weaker, perhaps by having increased the load on it!
Basics of Theory of Constraints 2 hour lecture by Eli Goldratt (the creator)
Theory of Constraints in Management (4 part web article)
all by Eli Goldratt
The Logical Thinking Process, by William H. Dettmer